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KMID : 0360419790150010045
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Korean Journal of Pharmacology
1979 Volume.15 No. 1 p.45 ~ p.56
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Pharmacological Action of Machilus Thunbergii Siebold Zuccarini
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조병헌/Cho, B.H.
김인호/이상복/조규철/이종화/Kim, I.H./Lee, S.B./Cho, K.C./Lee, J.H.
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Abstract
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With a view to searching after a new antihypertensive or hypotensive agents in the botanical crude plants, authors intended to reevaluate several natural products caltivated in Korea.
This experiment was undertaken to compare pharmacogical actions of Machilus thunbergii Siebold et Zuccarini with those of Magnolia obovata Thunberg in anesthetized rats and in normal mice.
Machilus thunbergii Sieb. et Zucc., a tree belonging to the Lauraceae family, is caltivated at Ull-ung Do, and their cortecies have been used as folk medicine mingled with those of Magnolia obovata Thunberg. These two cortecies have teen also applied in chinese medicine, it was advocated that these cortecies exerted good therapeutic effects on gastritis, convulsive abdominal pain, nausea, vomiting and urinary tract disorders.
Therefore, we intended to determine the pharmacological action of two palnt of different family each other, especially their effects on blood pressure and heart rate, and also their mechanism of action were observed. We studied their action with extracts of hexane(MTHE), ether(MTEE) , methanol(MTME) and water(MTWE) from Machilus thunhergii Sieb. et Zucc., and also fractionations of methanol(MOME), chloroform(MOCE) and water(MOWE) from Mapolia obovata Thunberg.
The results of this experiment were as follows;
1) MTME, when intravenously administered to rats, elicited the significant hypotensive responses dependent on the administered dosage.
2) MOWE was also exhibited the hypotensive effect dependent on the treated dose.
3) Depressor effect of MTME was blocked by pretreatment with hexamethonium.
4) The hypotensive response of MOWE was blocked by pretreatment with hexamethonium or hrdralazine.
5) HTME and MOWE werealso observed the anticonvulsive effect and sedative effect.
These results suggested that MTME may induce the hypotensive response via central sympathetic effect, but the site of action in brain are not clarified, and the hypotensive effect of MOWE may be due to dual mechanism of central sympathetic action and direct vasodilation of blood vessel.
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